A computational study of co-inhibitory immune complex assembly at the interface between T cells and antigen presenting cells
Fig 4
In addition to CTLA-4 and B7, we further introduced PD-L1 into the simulation system.
We systematically changed the surface density of PD-L1 and the binding affinity of its cis-interaction with B7. The tested results are summarized as two-dimensional heat maps. The contours in the maps indicate the number of PD-L1/B7 cis-interactions (A), the number of B7-B7 dimers (B) and the number of CTLA-4/B7 trans-interactions (C), respectively. Detailed color indices are listed on the right-hand sides of each map. The x axis represents the values of cis-binding affinity, and the y axis indicates the number of PD-L1 on the APC surface.