A computational study of co-inhibitory immune complex assembly at the interface between T cells and antigen presenting cells
Fig 3
We systematically changed the binding affinities in both CTLA-4/B7 trans-interactions and B7 homo-dimerization from 0 to -13kT.
The contours in the two-dimensional heat maps indicate the number of CTLA-4/B7 trans-interactions (A) and the number of B7-B7 dimers (B), respectively. Detailed color indices are listed on the right-hand sides of each map. The x and y axes represent the values of two binding affinities. The final configurations from some representative areas in the contour maps were selected. The configuration corresponding to the black arrows in the maps is shown in (C). The configuration corresponding to the while arrows in the maps is shown in (D). The configuration corresponding to the red arrows in the maps is shown in (E). Finally, the configuration corresponding to the blue arrows in the maps is shown in (F).