Gene variants of coagulation related proteins that interact with SARS-CoV-2
Fig 2
Predicted dock of VKORC1 and ORF7a transmembrane domain.
A. Five protein-protein docks depict one main binding site (teal, grey, yellow, green, blue). B. The lowest interface-energy model is shown as a surface representation. C. The lowest interface-energy model, with side chains shown in wheat for amino acids at the interface. D. Another view of the lowest interface-energy model, with side chains shown in wheat at the interface and hydrophobics shown in blue. Amino acids of VKORC1 necessary for vitamin K binding (83F, 80N, 135C, 55F) or warfarin binding (134V, 133I) are given in green.