The super repertoire of type IV effectors in the pangenome of Ehrlichia spp. provides insights into host-specificity and pathogenesis
Fig 7
Protein architecture network of Ehrlichia pT4Es shows a large number of interactions between protein domains.
This network of protein architecture of pT4Es is drawn using the hive plot algorithm, which is a rational visualization method for drawing networks based on their structural properties. Nodes are mapped to and positioned on radially distributed linear axes, and edges are drawn as curved links. Each node represents a specific domain or a list of specific domains (see table) found in Ehrlichia T4Es predicted by S4TE 2.0. Links between domains represent the association of these domains in the architecture of Ehrlichia pT4Es. Links between NLS, Coiled-coils, EPIYA and E block domains (the most abundant protein domains in Ehrlichia) and other nodes are red, blue, green and orange, respectively. Other links are pale grey. The table of domains identifies the protein domains for each node (numbered) and their occurrences in Ehrlichia spp predicted T4 effectomes. All the domains are ranked on the three axes (a1, a2, a3) according to the number of their links. Let X be the number of links between one domain and the others, X < 15 was represented on a1, 15 ≥ X ≤ 40 was represented on a2, and X > 40 was represented on a3, thus defining the most abundant domains. a1’, a2’ and a3’ split axes were drawn to represent the links between domains located on the same axis.