The super repertoire of type IV effectors in the pangenome of Ehrlichia spp. provides insights into host-specificity and pathogenesis
Fig 6
The distribution of Ehrlichia type IV effectomes according to local gene density and ΔGC content shows an enrichment of pT4Es in high GC content regions.
Distribution of E. canis str. Jake genes according to the length of their flanking intergenic regions (FIRs). All E. canis genes were sorted in two-dimensional bins according to the length of their 5′ (y-axis) and 3′ (x-axis) FIR lengths. For each gene, the ΔGC content was calculated by subtracting the GC content of a gene by the average of GC content of all the genes. The mean of ΔGC of genes in the bins is represented by a colour-coded density graph. GSR, GDR and IBR were defined as described for the analysis of local gene density. A colour was assigned to each of the three following groups: red to GDRs, orange to IBRs, and blue to GSRs. Specific pT4Es are represented with a dot circled in black. In the top right corner, a density graph indicates the density of pT4Es according to ΔGC content (red line) and the density of other genes (black line).