Network potential identifies therapeutic miRNA cocktails in Ewing sarcoma
Fig 5
Many of the most promising miRNA candidates repress large numbers of essential housekeeping genes.
We identified the top miRNA for treatment of Ewing sarcoma, ranked by their predicted disruption of the Ewing sarcoma cell signaling network. A: Boxplot showing the projected disruption in network potential for the top miRNA candidates (averaged across all samples). The heatmap on the x-axis describes the number of essential housekeeping genes that each miRNA is predicted to target. B: Scatterplot showing the relationship between projected network disruption and the number of putative mRNA targets for a given miRNA. C: Heatmap showing z-score normalized miRNA expression for 622 of the evaluated miRNA for the 6 cell lines under study. The Y axis is clustered by the projected ΔG associated with a given miRNA. There doesn’t seem to be a clear pattern of miRNA expression based on projected ΔG.