Estimating the cumulative incidence of SARS-CoV-2 with imperfect serological tests: Exploiting cutoff-free approaches
Fig 7
Conceptual diagram of the distribution of the quantitative test measures for control and case sera.
(A) Hypothetical probability density of quantitative test measures of control sera and three possible case sera distributions. (B) ROC-curves corresponding to the distribution of quantitative test measures of the control sera and each of the possible distributions for the case sera. (C) Visualization of the ‘maximal Youden’ and ‘high specificity’ cutoffs. (D) Visualization of the ‘maximal Youden’ and ‘high specificity’ cutoffs in the ROC curves.