Estimating the cumulative incidence of SARS-CoV-2 with imperfect serological tests: Exploiting cutoff-free approaches
Fig 1
Point-estimates of cumulative incidence using the cutoff-based methods and the mixture model.
Each violin represents 50 in silico serosurveys conducted with cohorts of 10, 000 virtual individuals and the points represent the median values. (A) Point-estimates of the cumulative incidence. The dashed line indicates the true cumulative incidence we assumed in the simulations. Please note that the scale of the y-axis differs between the sub-figures. (B) Size of the 95% uncertainty intervals. For the Rogan-Gladen and mixture-model estimates, the uncertainty intervals are the 95% confidence intervals, which we calculated with the bootstrap method (see Methods). For the Bayesian estimators, the uncertainty interval are the 95% credible intervals.