Mapping parameter spaces of biological switches
Fig 6
Graph adjacency and topology of parameter space.
Adjacency of all regions identified through the division of the entire parameter space under the sharp switch limit. Each node is colored based on how many distinct components exist for each defined region. Top right: inset for adjacency graph between the two components of region 27, along with steady state configurations of each adjacent region. Bottom: inset showing an example path for the diameter of the adjacency graph, along with the steady state configurations of each region along the path. Left: inset for adjacency graph for the singly-defined component of region 16, along with steady state configurations of each adjacent region. Top left: histogram of number of regions separating any pair of nodes in the graph. To see the individual labels for each region, see Figure A in S1 Text. For the corresponding parameter space graph in the case θ1 < θ2, see Figure C in S1 Text.