Biological impact of mutually exclusive exon switching
Fig 6
(A) The home page of MXE-MOD website. (B) The browser view allows the user to search different organisms and find a particular gene of interest. Annotations for the gene and associated MXE event have been integrated from different public resources: CATH, GENEONTOLOGY, Human Protein Atlas, DRUGBANK and Ensembl [31,46–49].(C-D) Detailed ‘MXE model’ pages for 2 different examples in the website. We can see the alternative MXE structure superposed in (C). We can see the variable PPI residues shown in space fill in the website in (D). MXE-MOD utilises the PV javascript viewer [50]. For both examples we show the expression patterns for the MXE isoform groups at different stages of development from RNA-seq and proteomics derived datasets. RNA-seq data is obtained from ModEncode resource [51] and proteomics data from the DDIP consortium (https://ddip-proteome.org) led by Simon Hubbard, Manchester University, UK.