Biological impact of mutually exclusive exon switching
Fig 3
Number and names of CATH superfamilies common to multiple species analysed in this study.
MXEs from different species were mapped to CATH domain superfamilies. CATH superfamilies are groups of protein domains with clear evidence of homology. The CATH superfamily code is denoted by four numbers corresponding to each level in the CATH classification (i.e. 3.20.20.120). At the top of the hierarchy is the class level where structural domains are classified based on their secondary structure content. The second level of the hierarchy is the architecture level given by the global arrangement of secondary structures in 3D space. This is followed by the topology level where domains with similar folds (which takes into account the 3D arrangement, orientations and connections between the secondary structures) are grouped together. The fourth level is the homologous superfamily level where domains are deemed homologous. A website tool (http://bioinformatics.psb.ugent.be/webtools/Venn/) was used to draw this Venn diagram.