Biological impact of mutually exclusive exon switching
Fig 1
Identification of variable residues and possible functional effects of variable residues.
(A) Identifying the variable residues for an MXE event (MXE-specific residues). The same colour code is used throughout the paper. The MXE region from the pair of proteins generated from the splicing are shown in purple or yellow. Variable residues from the MXE event are shown in red. (B) Possible functional effects of variable residue switching assessed in this paper include altering PPI (Protein-Protein interactions), CSA (catalytic residues from the Catalytic Site Atlas[21]), PSI (Protein-Small molecule Interactions), Allosteric, PTM (Post-Translational Modification) and FunSites (predicted functional sites from functional families (FunFams)).