Data-driven method to infer the seizure propagation patterns in an epileptic brain from intracranial electroencephalography
Fig 2
Example of a simulated seizure in real brain network.
(A) The region excitabilities c are randomly sampled from a standard normal distribution. Brain regions are located on the vertical axis, colored bars indicate the anatomical grouping of the regions. (B) Slow variable z, simulated using the sampled excitabilities and strong coupling excitation function (see Fig 2 in S1 Text) on a brain network of subject 1. (C) Seizure state of the regions, obtained by thresholding the slow variable at z = 1. Due to the elevated excitability of the regions, the seizure starts in the Rhinal cortex in left temporal lobe (white triangle), and with some delay in Pars orbitalis in left frontal lobe (light green triangle). Eventually, large portion of the left temporal lobe is recruited (magenta circle). Abbreviations: Lxx/Rxx—left/right hemisphere, Fr—frontal lobe, Ci—cingulate cortex, In—Insula, Te—temporal lobe, Pa—parietal lobe, Oc—occipital lobe, Sc—subcortical structures. See Table 2 in S1 Text for a full list of regions.