SAveRUNNER: A network-based algorithm for drug repurposing and its application to COVID-19
Fig 6
The bar plots show the values of the non-Euclidean separation distance computed for the SARS-CoV (a) and SARS-CoV-2 (b) disease module with respect to all the other disease modules analyzed in this study. We applied a degree-preserving randomization procedure to assess the statistical significance of each separation value, and we calculated all p-values by applying a two-tailed z test. The stars flag levels of significance for three of the most commonly used levels: p-value < 0.05 is flagged with one star (*); p-value < 0.01 is flagged with two stars (**); and p-value < 0.001 is flagged with three stars (***).