SAveRUNNER: A network-based algorithm for drug repurposing and its application to COVID-19
Fig 3
(A) The SARS-CoV-associated disease genes subnetwork in the human interactome. Light blue nodes represent SARS-CoV-associated proteins that can be directly targeted by at least one FDA-approved drugs (targetable); green nodes represent SARS-CoV-associated proteins that do not have any known ligands and then cannot be directly targeted by drugs (non-targetable); grey nodes represent interaction partners of SARS-CoV-associated proteins in the human interactome (neighbor). (B-C) KEGG human pathway enrichment analysis for SARS-CoV-associated disease genes. The dot plots of the top 30 enriched KEGG pathways (p-value ≤ 0.05) obtained for the 21 targetable SARS-CoV-associated disease genes (B) and for the total 41 SARS-CoV-associated disease genes (C). The y-axis reports the annotation categories (KEGG pathways) and the x-axis reports the gene ratio (i.e., the number of genes found enriched in each category over the number of total genes associated to that category). The color of the dots represents the adjusted p-values (FDR), whereas the size of the dots represents the number of genes found enriched in each category.