Modulation of the dynamics of cerebellar Purkinje cells through the interaction of excitatory and inhibitory feedforward pathways
Fig 6
PC temporal spike patterns affected by MLI and STP.
(A) Schematic illustration of feedforward MLI inhibition and GC excitation when GC-PC STP is off. (B) PC membrane potential traces gradually delayed by different levels of MLI inhibition with an input of 10 Hz Poisson spikes. (C, D) Similar to (A, B) but for MLI off and STP on with varying excitation at different levels of Uexc. (E) Interspike interval (ISI) distribution of the population PC spikes under four different settings with/without excitatory STP and/or MLI (left). (Right) The change of ISI, CV (coefficient of variation), and CoV2 (local regularity) over a range of GC inputs, averaged over the population of PCs (mean±SD, n = 50).