Modulation of the dynamics of cerebellar Purkinje cells through the interaction of excitatory and inhibitory feedforward pathways
Fig 4
PC phase modulation affected by MLI and STP.
(A) PC population firing rate (n = 50) in response to GC inputs sinusoidally-modulated with 1, 10, 20 and 30 Hz, from 100 independent input spike trains. Solid color lines are fitted with sinusoidal functions. (B) Normalized fitting curves from (A) show phase shifts relative to the input. (C) Phase shift as a function of input frequency in four different conditions (left), and the corresponding changes of phase shifts relative to the baseline (right). (D) Phase shift changed over a range of excitation Uexc and inhibition WMLI. (Left) Phase shift over a sequence of input frequencies with different levels of excitation and inhibition in three conditions. (Right) Phase shift changed by combined MLI and STP, where each inner rectangle represents a PC phase shift spectrum over the same sequence of input frequencies (0-30 Hz).