Inferring the structures of signaling motifs from paired dynamic traces of single cells
Fig 4
Validation of MISC with additional biological motifs.
(A) Cascade motif. The cascade motif creates a delay in the output, Z. Upper left, ball and stick model and arrow representation of the motif. Lower Left and Middle, an example of the motif. Right, Known and predicted motif. Asterisks indicate greater than 50% confidence in that connection. (B) Feedback motif. The feedback motif creates a persistence in the response of Z. Upper left, ball and stick model and arrow representation of the motif. Lower Left and Middle, an example of the motif. Right, Known and predicted motif. Asterisks indicate greater than 50% confidence in that connection. (C) Coherent Feed Forward Loop (CFFL) motif. The CFFL creates a delay in the onset of Z, but no delay in the offset. Upper left, ball and stick model and arrow representation of the motif. Lower Left and Middle, an example of the motif. Right, Known and predicted motif. Asterisks indicate greater than 50% confidence in that connection.