Design principles for the glycoprotein quality control pathway
Fig 5
Optimal performance and corresponding parameters.
Maximum folding fraction fmax at Punfolded = 1, (blue curves, left blue vertical axis), and corresponding optimal rate constants, ki (red curves with markers, right red vertical axis) as cycle conditions are varied for the physiological model. (A) varies protein production rate kpt for fixed mf = 10−3 and kf = 1, (B) varies protein folding rate constant kf for fixed mf = 10−3 and kpt = 0.9, and (C) varies misfolded fraction mf for fixed kpt = 0.7 and kf = 1.