Design principles for the glycoprotein quality control pathway
Fig 3
Untagged protein binding and reversible chaperone binding can be disadvantageous.
(A) Maximal achievable folding fraction at fixed unfolded protein, Punfolded = 1, plotted versus the untagged rebinding rate k-r, as cycle parameters kc, k-c, kr, kg, k-g, and kd are free to vary. Other curves show similar behavior when folding and production rates are altered. (B) Folding efficiency is plotted as a function of unbinding rate k-c. Cycle parameters kc, kr, kg, k-g, and kd are free to vary. Folding rate kf and production rate kpt are held constant as indicated. The misfolding fraction is set to mf = 0.001.