Independent component analysis recovers consistent regulatory signals from disparate datasets
Fig 2
Comparison of IC gene weightings for iModulons enriched with genes in the CysB regulon.
(A) Scatter plot between IC gene weightings for CysB-linked iModulons across all five datasets. Genes in the published CysB regulon are colored in red. For comparisons in the first column involving the MA-3 dataset, genes regulated by any of the following regulators are colored in blue: MetJ, TrpR, GlpR, ArgR, Lrp, CysB, leu-tRNA-mediated transcriptional attenuation, or thiamine riboswitch. All other genes are black. Dashed lines indicate iModulon thresholds. Gray solid lines indicate the 45-degree line of equal gene weightings. (B) Scatter plot between IC gene weightings for the CysB iModulon in MA-3 compared to a linear combination of 10 ICs from RNAseq-1 (see S1 Table). Color scheme is identical to panel (A).