Mitochondrial depolarization promotes calcium alternans: Mechanistic insights from a ventricular myocyte model
Fig 3
MCU upregulation promotes Ca2+ alternans through Ca2+- dependent opening of mPTP.
Dependence of Ca2+ alternan amplitude on αMCU and αmPTP.
is calculated as the difference between the last two Ca2+ transient peaks in a simulation of 30 sec. PCL = 500 ms.