Mitochondrial depolarization promotes calcium alternans: Mechanistic insights from a ventricular myocyte model
Fig 2
Effect of cytosolic ROS signaling on the genesis of Ca2+ alternans.
A. Bifurcation diagram of peak values of Ca2+ transients vs. αmPTP for free-running ROS (black) and fixed ROS = 0.1 μM (red), respectively. B. Bifurcation diagram of peak values of Ca2+ transient vs. αmPTP with free-running ROS, but the redox effect of ROS only exerted on RyRs (green) or SERCA (blue), respectively. The PCL is 500 ms. The total simulation time for each simulation is 30 sec.