miRNA normalization enables joint analysis of several datasets to increase sensitivity and to reveal novel miRNAs differentially expressed in breast cancer
Fig 8
Impact of normalization on the correlation between hsa-miR-29b expression and its in-silico predicted targets according to TargetScan.
Scatter plot of spearman correlation on normalized miRNA or unnormalized miRNA expression. If the target mRNA appears in TargetScan it is highlighted in orange. The marginal distributions are shown parallel to the axes and corresponding Kolmogorov-Smirnov test p-values display an overall lowered correlation for TargetScan candidates on normalized data.