Directed attenuation to enhance vaccine immunity
Fig 1
Typical dynamics of an acute infection.
Virus (V) is shown in red, innate immunity (Z) in black and adaptive immunity (X) in blue. The scale for virus and adaptive immunity is fold change over the initial value (V(0) and X(0) are set to 1). The scale for innate immunity is percent of its maximum possible value (100), and in this simulation Z attains only about 10% of its maximum. Parameters are chosen for a biologically relevant regime as described earlier [36] and are shown in Table 1.