Conformational plasticity and dynamic interactions of the N-terminal domain of the chemokine receptor CXCR1
Fig 5
Residue-wise interactions of the N-terminal region of CXCR1 with IL8.
(A) Residue-wise contact probabilities of the N-terminal region interacting with IL8. (B) Predicted chemical shift changes in the N-terminal region between the apo- and ligand-bound state. (C) The N-terminal residues with chemical shift perturbations above a cutoff (dotted lines in panel (B)) mapped onto the receptor structure. The cyan transparent spheres represent residues from the predictions. The orange and yellow spheres represent residues showing significant chemical shift changes as reported from NMR measurements [37,42]. See Methods and text for more details.