Conformational plasticity and dynamic interactions of the N-terminal domain of the chemokine receptor CXCR1
Fig 4
Conformational landscape of the N-terminal region of CXCR1.
Population density map of the conformations sampled by the N-terminal region plotted as a function of backbone RMSD of the N-terminal region and the distance between side chains of two representative residues (Met1 and Asp26) for (A) apo-CXCR1 and (B) IL8-bound CXCR1. The most populated conformations are shown below the plots. The N-terminal region is shown in cyan and rest of the receptor is in pink. See Methods for more details.