Voxelized simulation of cerebral oxygen perfusion elucidates hypoxia in aged mouse cortex
Fig 5
Validation of oxygen perfusion simulations against three sets of experimental data.
The experimental results were obtained with 2-photon phosphorescence lifetime oxygen imaging. The simulations were performed in planes with two different resolutions; a coarse 20x20 and a dense 200x200. There is reasonable agreement between experimental and simulated oxygen fields (2.9±1.4% error). Manual matching between the concentration profiles was used to determine tissue diffusivity, reaction rate, and mass transfer coefficient. The 3D perspective illustrates the steep concentration gradients along two penetrating arterioles.