Voxelized simulation of cerebral oxygen perfusion elucidates hypoxia in aged mouse cortex
Fig 4
Oxygen distribution throughout a microvascular network specimen (E4.1) from the vibrissa primary sensory cortex in mouse.
A) Visualization of a portion of the extravascular space with a block cutout defined by 5 observation planes at different cortical depths (120, 280, 480, 680, and 880μm below the cortical surface). Color coding corresponds to oxygen tension in blood vessels. B-F) The visualization of oxygen distribution at the individual layers. C) Steep oxygen gradients form around penetrating arterioles–marked with red arrows. E) Oxygen tension is also elevated around veins–marked with blue arrows. In the deeper regions E-F) a hypoxic valley begins to form seen as deep blue basins.