A novel stochastic simulation approach enables exploration of mechanisms for regulating polarity site movement
Fig 8
Increasing the rate constant of Cdc42T-GEFm association (k4a) induces an abrupt change in patch mobility.
(A) Patch centroid diffusivity as a function of the number of GEF molecules for the model that includes Reaction 7 (Updated model, black) and the same model but setting k4a = 0 (red). (B) Patch diffusivity as a function of k4a for simulations with GEF = 100. Error bars are standard errors from the least-squared fit used to compute Dpatch.