Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation
Fig 3
Macrophage locations within simulated granulomas at 50 days.
Cells were characterized as “central” if they were located less than 80% of the radius of the granuloma away from center or “peripheral” if they were between 80% and 100% of the radius. Remaining cells were categorized as “Not in granuloma”.