Multi-scale modeling of macrophage—T cell interactions within the tumor microenvironment
Fig 1
Model schematic and representative simulation result.
(A) Model schematic. T cells secrete IFN-γ, which promotes M1 differentiation. Tumor cells and M2 macrophages secrete IL-4, which promotes M2 differentiation. T cells kill tumor cells. M1 macrophages promote T cell function, while M2 macrophages inhibit it. (B) Representative spatial distribution of cells once the tumor reaches the equilibrium state. Tumor cells (black), T cells (yellow), active T cells (red), M0 macrophages (blue), M2 macrophages (purple). There are no M1 macrophages present at the end of this simulation.