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Modeling the circadian regulation of the immune system: Sexually dimorphic effects of shift work

Fig 7

Knockout experiment at CT12.

Model simulations of the time course of IL-10 (A) and the damage marker (B) in response to endotoxin dose 3mg/kg administered CT12. Three scenarios are simulated: Rev-Erb KO, Cry KO and Ror KO.

Fig 7

doi: https://doi.org/10.1371/journal.pcbi.1008514.g007