Modeling the circadian regulation of the immune system: Sexually dimorphic effects of shift work
Fig 1
Regulatory network of the coupled immune system and circadian clock.
Schematic diagram of the acute immune response model (orange shapes) and the circadian clock (blue shapes) in the lung of a rat. In the circadian clock model, slanted boxes denote mRNAs; blue rectangles denote proteins; ovals denote protein complexes. Dotted arrows represent transactivation; blunt dashed arrows represent inhibition. In the acute inflammation model, P denotes endotoxin; D, damage marker; N, activated phagocytic cells; CA, slow-acting anti-inflammatory cytokines.