Activity-mediated accumulation of potassium induces a switch in firing pattern and neuronal excitability type
Fig 1
Response of the model to a step current of 2 μA/cm2 input as shown in the top.
A. Voltage trace (V) with reversal potentials for sodium (Orange) and potassium (Blue).B. Firing rate (Fr) of neuron model. C. Intracellular sodium (Orange) and extracellular potassium (Blue) concentration (C) dynamics. D. Spike amplitude and reversal potential for sodium (Orange) for the trace shown in A. E. First and last spike (peaks aligned).