PIEZO1 and the mechanism of the long circulatory longevity of human red blood cells
Fig 10
Simulating the lifespan of a seven day irreversible sickle cell (ISC), showing the predicted changes in RCV (black) and density (red), (panel A), and in the cell concentrations (panel B) of K(CK), of Na(CNa), and of permeant anion (CA). The parameters used were: Lifespan duration, 168h (7 days); Data output periodicity: 60m; kNaP, 2e-3/m; kCaP, 5e-5/m; TNaP, 5760m (4 days); PIEZO1 open state, 30s; PzCa, 5.7/h; PzA, 50/h; PzNa, 0; PzK, 0.