PIEZO1 and the mechanism of the long circulatory longevity of human red blood cells
Fig 7
Predicted lifespan changes in cell pH (pHi) and in the intracellular concentrations of permeant anions A- (CA) and of H+ (CH) for the conditions of the Reference pattern (Fig 3).
Besides minor contributions from variations in haemoglobin buffering, most changes in CH are driven primarily by changes in the anion concentration gradient (rA) acting through the Jacob-Stewart mechanism causing rH to approach rA during periods between capillary transits (User Guide). At constant MA all anion gradient changes apply to CA, thus generating similar time-courses for CA and pHi (Panel A), or mirror image changes for CA and CH (Panel B).