PIEZO1 and the mechanism of the long circulatory longevity of human red blood cells
Fig 5
Effects of pump decay rates and timings, and of Gardos channel inhibition on the predicted lifetime pattern of cell volume change.
Parameter changes are listed relative to reference curve 1. For the simulation shown in curve 6 the Gardos channel Fmax was changed from 30/h to zero in the Reference State. For curves 3 and 4 TNaP was set to zero and the decay rates to 7e-6/min and 1e-5, respectively. For curves 2 and 5 PMCA decay rates were set to 1e-5 and 5e-6, respectively.