Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy
Fig 4
Single-reaction deletion identifies and categorizes context-specific and shared key reactions.
(A) Changes in model validation percent after one-by-one removal of each 174 intermediate reactions in the hypertrophy network for ISO (cross), PE (circle), AngII (triangle), and stretch (square) contexts. (B) The key reactions in ISO-specific and (C) AngII-specific contexts have been visualized on the hypertrophy network map. The thicker and bolder red, or blue arrows illustrate more decrease, or increase in validation percent, respectively, after removing each reaction.