Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy
Fig 3
Classified qualitative validation reveals incomplete parts of the ISO-specific network.
Comparison of model predictions with 75 experimental data points in three classes of data including input-output (7/7 correct prediction), input-intermediate (27/30 correct prediction), and intermediate-inhibition (22/38 correct prediction) after isoproterenol stimulation. The red, blue, and gray boxes illustrate increase, decrease, and no change, respectively. In the model, changes in the measured node activity greater than +1% or smaller than -1% have been considered as an increase or decrease, respectively. In experimental data, statistically significant changes in comparison with the control have been considered as an increase or decrease based on the direction of changes.