Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy
Fig 1
(A) Four-stage revision process to derive a hybrid context-specific model with an automated validation module as a core, and context-specific data and signaling network interaction graph as inputs. (B) Schematic of context-specific global sensitivity analysis (GSA). Two-step Morris-Sobol global sensitivity analysis identifies key reactions of model validity in each context and reduces the model dimension for calibration of main parameters with semi-quantitative data.