MetGEMs Toolbox: Metagenome-scale models as integrative toolbox for uncovering metabolic functions and routes of human gut microbiome
Fig 4
MetGEMs toolbox predicted metabolic functions and routes from Thai population-based allergy birth cohort study.
Note: Boxplot represents relative abundances of enzyme functions predictions (KO IDs and EC numbers) between healthy and atopic dermatitis samples during 9–19 months. Wilcoxon rank-sum test is used for statistical significance. * and ** correspond to p-value < 0.01 and p-value< 0.005, respectively. (A) The predicted KO IDs including triosephosphate isomerase (K01803), undecaprenyl-diphosphatase (K06153), ribulose-phosphate 3-epimerase (K01783), aspartate carbamoyltransferase (K00608), aspartate carbamoyltransferase catalytic subunit (K00609). (B) The predicted EC numbers including undecaprenyl-diphosphate phosphatase (EC: 3.6.1.27), triose-phosphate isomerase (EC: 5.1.3.1), aspartate carbamoyltransferase (EC: 2.1.3.2), amidophosphoribosyltransferase (EC: 2.4.2.14), triose-phosphate isomerase (EC: 5.3.1.1) (C) The predicted metabolic routes including Superpathway of pyrimidine deoxyribonucleoside salvage (PWY-7200), L-arginine biosynthesis III (via N-acetyl-L-citrulline) (PWY-5154), L-ornithine biosynthesis I (GLUTORN-PWY), Superpathway of pyrimidine nucleobases salvage (PWY-7208), and Superpathway of sulfate assimilation and cysteine biosynthesis (SULFATE-CYS-PWY).