MetGEMs Toolbox: Metagenome-scale models as integrative toolbox for uncovering metabolic functions and routes of human gut microbiome
Fig 2
A metabolic diversity of assessed most up-to-date GEMs.
(A) A Pearson’s correlation analysis between KO IDs and EC numbers identified in the evaluated 818 GEMs across different taxonomic classes at a phylogenetic-tree scale. Full details of correlation analysis and goodness of fit between KO IDs and EC numbers by scatter plot can be seen in S1 Fig. Note: In this Figure, the blue and green lines indicate the numbers of KO IDs and EC numbers, respectively. PCC stands for Pearson’s correlation coefficient. The phylogenetic-tree scale is built from 773 genomes with coding sequences available in AGORA collections visualized by iTOL [26]. (B) A bar graph explicates the selected taxonomic classes in context of the average numbers of KO IDs and EC numbers. (C) A bar graph illustrates a comparison of Core- and Pan-Function computational approaches in terms of the average numbers of KO IDs across different genera.