MetGEMs Toolbox: Metagenome-scale models as integrative toolbox for uncovering metabolic functions and routes of human gut microbiome
Fig 1
A schematic workflow of a development MetGEMs toolbox.
The computational framework for the developed MetGEMs toolbox is divided into five different sections, namely 1) the assessed and evaluated GEMs, 2) the constructed MetGEMs network as reference database towards implementing MetGEMs toolbox, 3) the validated MetGEMs toolbox’s prediction capability with shotgun metagenomic sequencing data, 4) using MetGEMs toolbox for assigning enzyme functions and relevant functional categories related human gut microbiome, and 5) annotating putative enzyme functions related in allergic disease using the MetGEMs toolbox as described in following.