Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans
Fig 7
Transgenic mice share a higher similarity with human breast cancer patients than Control mice.
(A) The number of different human α-β pairs shared with our mouse data within the Control group (blue bar) and the Transgenic group (red bar). (B) The percent of convergent recombined (CR) human α-β pairs in the Control and Transgenic mice. (C) The percent of the different Public groups (Private, Public-Inclusive and Public-Exclusive) in the Control group (blue bars) and the Transgenic group (red bars). (D) Distance networks of all the α-β pairs shared with our mice subsampled data that appear only in the Control group (blue network), only in the Transgenic group (red network) and in both groups (green network).