Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans
Fig 6
The relationship between TCR clones and different breast cancer stages.
Public repertoires of the TCGA-associated TCR clones and their subtypes are shown in tumor-developing mice and in Control mice for α chain (A) and β chain (B). Frequency of Convergent recombined clones shared between TCGA samples and mouse samples in α (C) and β chain (D). (E) Frequency of shared clones between TCGA samples and tumor-developing mice in different stages of breast cancer in α chain clones. For each sample, we calculated the number of shared clones according to the following formula: (Shared clones between sample and stage) / (# of clones in a sample x # of total cases of a stage).