Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans
Fig 5
Cross-species tumor-associated clones.
(A) The averaged predictive binding score to tumor peptides of tumor-associated cross-species sequences (right bar) and 5 random subsets of sequences. (B) The averaged Jaccard overlap index between control-exclusive sequences and tumor exclusive sequences to breast cancer samples (left plot) and Melanoma samples (right plot). (C) The frequency of highly abundant sequences from ‘Transgenic Old’ samples and random sequences in breast cancer samples (left plot) and melanoma samples (right plot).