Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans
Fig 3
Comparing human T cell repertoire data and mouse T cell repertoire data.
To learn more about the connection between the repertoires of mouse mammary tumor and human breast cancer, we studied the three different types of datasets (left to right): (1) TCR β-seq data from 50 breast cancer patients from 3 different studies, in which different conditions and different tissues were studied. (2) Single-cell RNA-seq TCR data of 3 breast cancer patients obtained from Azizi et al. (3) TCR sequences extracted from RNA-seq data of breast cancer patients obtained from The Cancer Genome Atlas (TCGA).