Drug2ways: Reasoning over causal paths in biological networks for drug discovery
Fig 4
Distribution of node types and relationships in the In-House and OpenBioLink networks.
a) The OpenBiolink KG contains a greater proportion of PubChem drugs relative to the In-House network which solely contains drugs from DrugBank. While the number of proteins in each of the two networks is comparable, indications are more numerous in the In-House network with respect to the OpenBioLink KG. Phenotypes for the In-House network were sourced from OpenBioLink, and as such, are equivalent in number. b) The total number of drug-protein interactions is greater in the OpenBioLink network than in our In-House. A greater proportion of protein-protein interactions are present in the In-House network, as are the number of protein-indication edges while the number of protein-phenotype interactions are nearly equivalent.