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Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding

Fig 8

Square-wave bursting in the CSC model defined by the full system (1) when gK(Ca) is varied.

A) Magnification of the set of isolas of square-wave BPOs in the left black boxed region of Fig 7. The top segment of each isola is an envelope of stable periodic orbits (solid) that becomes unstable (dotted) at a saddle-node bifurcation of periodic orbits (SNPi, i = 3, …) from the right and period-doubling bifurcation (PDj, j = 1, …) from the left. The number of spikes for each isola is indicated by the number on top. B) Time courses of two square-wave BPOs when the number of spikes per burst is 12 (top) and 3 (bottom) obtained at gK(Ca) = 0.9 μS.cm−2 and gHVA = 6 μS.cm−2, respectively.

Fig 8

doi: https://doi.org/10.1371/journal.pcbi.1008463.g008